Caffeine is indeed more polar, on top of your observations in hplc, you can also see this in how soluble each is in water. It's pretty clear that caffiene is more polar.
Physical Properties - Caffeine: The Molecule
As you can see from its structure here:
Is caffeine polar. The oxygen and nitrogen molecules have a stronger polarity than carbon, allowing them to slightly pull the electrons towards them in their covalent bond. Answer #1 yes, caffeine is a polar molecule. Caffeine has a solubility of 140mg/ml in dichloromethane which is much more than its solubility of water.
Peter fink’s links seem to confirm this. However, caffeine has been found to be more polar than aspirin, according to an article published in the journal chemical science. Dispersion forces happen because electrons are always in motion, one end of a molecule is either temporarily positive or negative.
So can caffeine worsen your bipolar disorder? 3 more posts from the chemhelp community 45 posted by Some evidence suggests that caffeine may worsen mood destabilization in bipolar disorder, potentially leading to manic episodes.
If you’re looking for a more chemically accurate answer, the reason is because in the caffeine molecule, the nitrogen and oxygen are more strongly polar than the carbon, which allows them to more firmly pull the covalent electrons from the carbon counterparts. National center for biotechnology information. Caffeine can also disrupt bipolar disorder treatment, resulting in.
In this molecule, london dispersion forces, dipole dipole forces, and hydrogen bonding are all present. The atom with a higher electronegativity will have a slightly more negative charge due to the attraction of more electrons, causing an unequal sharing of electrons. Caffeine raises dopamine levels in the brain, which can cause increased anxiety, restlessness, and thus induce mania or hypomania (which can then bring on a loss of appetite when you have bipolar disorder ).
Caffeine is water soluble, so it is a polar compound. Polar molecules typically have one or more highly electronegative atoms surrounded by. But in any case, caffeine is not a very polar molecule (if it were it would not partition favorably from water into chcl3), and i suspect it is much more soluble in chcl3 than in etoh.
On the internet i've seen a lot of people using. This will give those atoms a slightly negative charge while giving the carbon a positive charge. The large plane of caffeine’s chemical structure consists mostly of hydrocarbons.
Because of this, any two molecules can have a weak bond between them. While dichloromethane is not as polar as water yet it is a hydrocarbon. A person with bipolar is far more sensitive to any substance that mimics that of an amphetamine, and coffee is one of those substances.
It really depends on you,. So, you can consider dichloromethane as a polar hydrocarbon. One important application of this is in decaffeination of coffee.
No single molecule is entirely nonpolar or entirely polar.
Chemitstry: Caffeine
Which Compound Do You Expect To Be Most Polar: Aspirin, Acetaminophen, Or Caffeine? Explain. | Homework.study.com